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Red yeast rice is Chinese traditional herbal medicine and food.
It is fermented in steamed rice with monascus purpureus went sp.
It has more than a thousand years of using history in China.
In 70s last century, A Japanese scholar, professor Endo found out
monacolin-k from the metabolins of monascus sp. This compound can
lowers the level of serum cholesterol significantly. In 1985, American
scientists Dr.Goldstein and Dr.Brown discovered the mechanism of
monacolin-k in inhibiting the synthesis of cholesterol in human
body. Due to this reason they won the Nobel Prize. And then, red
yeast rice is well known and popular in the world.
The study of Dr. Goldstein & Dr. Brown shown that Monacolin-k
is a pro-drug(Molecular structure,fig1.). It has no activity and
need to be hydrolyzed by carboxyesterases, then converts to active
Mevinolinic Acid (MVA)(Molecular structure,fig2.), and then it can
exerts its lipid-reducing effect in body.
 
Molecular structure,fig1. Molecular structure,fig2.
But, all these esterases showed evidence of inter-individual variability.
Even in some individuals, the activities of these esterases were
completely missing. In this way, the blood-lipid lowering effect
of monacolin-k must be different in the different individuals. If
the level of your esterases is higher, Monacolin-k will be effective
for you; if the level of your esterases is lower or missing; Monacolin-k
will be not effective for you and, the drug will be harmful to your
liver and kidney.
The occurrence of Monacolin-k brings a revolution in the preventing
and curing of cardiac-cerebral vascular diseases. But it is dancing
with bonds, so no warmed applauses will be expected. Compare with
other blood-lipid lowering agents, it somewhat likes ＾the pot calls
the kettle black￣.
How to release all the contributions of Monacolin-k to human health?
It¨s a practical problem and need to be settled.
Eight years ago, we found out a trace quantity and unstable component
from my natural fermented red yeast rice. The MS testing shown that
its molecular structure (fig3.) is complete fits close with Mevinolinic
acid! The occasional discovery greatly encouraged me: if I can produce
it in bulk and keep its natural property, it will inhibits HMG-CoA
reductase directly thus to inhibits the synthesis of cholesterol
and need not to be hydrolyzed by esterases. That is, not like Monacolin-k,
it will be effective for all hyperlipaemia patients whether its
esterases level is higher or lower and, it will brings no harms
to human liver & kidney. It will instead of Monacolin-k in using,
we called it MVA.
 Molecular
structure,fig3.
In the following years, we still work like a horse in this field
and is approaching the aim step by step.
By now, in my noble-series red yeast rice, the ratio of MVA in total
inhibitors accounts for 50%, in my masterwork-series red yeast rice
the ratio accounts for 80%.
We¨ve opened the bonds which trussed the actress¨s feet and, she¨ll
does her best to dance for all patients.
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